Chemistry, Biology and Cancer: The Bond

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Edited By: David Selwood.

Inside My Lab: Derek Tan

Impact factor: 2. Online ISSN: On the Cover Skip slideshow. The cover image is based on the Research Article Interdomain twists of human thymidine phosphorylase and its active-inactive conformations: Binding of 5-FU and its analogues to human thymidine phosphorylase versus dihydropyrimidine dehydrogenase by Tiffany Tozer et al. A Heale and Tiffany M Tozer. The front cover image is based on the Special Issue Article Label-free molecular probe based on G-quadruplex and strand displacement for sensitive and selective detection and naked eye discrimination of exon 2 deletion of AIMP2 by Ruimin Zang et al.

The back cover image is based on the Special Issue Article Design of multi-drug combinations for poly-pharmacological effects using composition-activity relationship modeling and multi-objective optimization approach: Application in traditional Chinese medicine by Bo Fan et al. The assay revealed that lipopolysaccharides in Ashwagandha, an Ayurvedic medicinal plant, activate macrophages in a manner similar to monophosphoryl lipid A, a clinically used vaccine adjuvant.

The figure shows the proposed structure and the relevant physicochemical properties of the complex.

Publication details

The biological evaluation demonstrated high affinity for the tumour, resulting in a promising candidate for breast cancer imaging. This might facilitate the switch from replicative to translesion synthesis polymerase binding at stalled replication forks. The lab is investigating the structure and binding properties of ubiquitylated p Francisco Blanco.

Email: fblanco cicbiogune. Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.

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Mortuza, Gulnahar B. Surfing Transcriptomic Landscapes. MABS Production of meganucleases by cell-free protein synthesis for functional and structural studies Villate, Maider; Merino, Nekane; Blanco, Francisco J. Learn about career opportunities in the Chemical Biology Program. Our chemical biology efforts focus on developing new classes of small molecule modulators, like allosteric and covalent inhibitors and the degrader molecules, for challenging targets.

Protein-protein interactions PPIs mediate many of the cellular processes that are misfiring in cancer and other diseases. Yet, PPIs are notoriously difficult to target with small molecules.

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Our researchers are developing stapled peptides and other innovative strategies to better understand, control, and target PPIs. Our structural biology and proteomics faculty solve structures of key molecular players that drive cancer and map their interactions.

We use structural and proteomics information to frame and assist small molecule development and design, and as a window into selectivity, specificity, and the mechanism of action. Development of new pharmacologic agents requires extensive exploration of the chemical space to optimize the drug-like properties.

James A. Kelley, Ph.D.

Our medicinal chemistry faculty and the Medicinal Chemistry Core have expertise in transforming tool compounds into preclinical candidates. Our faculty is developing new organic and analytical methodologies, as well as investigating basic principles of chemical and biological mechanisms, which serve as an essential fuel for our translational efforts.

At monthly faculty meetings, chemical biologists and their guests discuss ongoing research in their labs to foster collaboration and translation of chemical biology principles into basic and clinical advancements. They're seeking out what might be driving a cancer tumor, and the hope is that these molecules might someday be powerful cancer-fighting drugs.

ACS Chemical Biology

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